Unrelated donor stem cell transplantation in acquired severe aplastic anemia: a systematic review
نویسندگان
چکیده
منابع مشابه
Unrelated donor stem cell transplantation in acquired severe aplastic anemia: a systematic review.
Acquired severe aplastic anemia is a rare disease characterized by an immune-mediated functional impairment of hematopoietic stem cells. Transplantation of these cells from unrelated donors is a treatment option frequently offered to patients after failed immunosuppressive therapy. The aim was to investigate the outcome of these patients treated with unrelated donor transplants. Systematic lite...
متن کاملEffect of stem cell source on outcomes after unrelated donor transplantation in severe aplastic anemia.
Outcome after unrelated donor bone marrow (BM) transplantation for severe aplastic anemia (SAA) has improved, with survival rates now approximately 75%. Increasing use of peripheral blood stem and progenitor cells (PBPCs) instead of BM as a graft source prompted us to compare outcomes of PBPC and BM transplantation for SAA. We studied 296 patients receiving either BM (n = 225) or PBPC (n = 71) ...
متن کاملAcceptable HLA-mismatching in unrelated donor bone marrow transplantation for patients with acquired severe aplastic anemia.
We retrospectively analyzed the effect of HLA mismatching (HLA-A, -B, -C, -DRB1, -DQB1) with molecular typing on transplantation outcome for 301 patients with acquired severe aplastic anemia (SAA) who received an unrelated BM transplant through the Japan Marrow Donor Program. Additional effect of HLA-DPB1 mismatching was analyzed for 10 of 10 or 9 of 10 HLA allele-matched pairs (n = 169). Of th...
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introduction: severe acquired aplastic anemia (saa) is a rare disease and matched related hematopoietic stem cell transplantation (hsct) is the treatment of choice especially in pediatric patients. immunosuppressive therapy is the alternative treatment in patients who do not have a donor. we retrospectively analyzed patients who received allogeneic hsct at our institution. methods: between 1991...
متن کاملTRANSPLANTATION Acceptable HLA-mismatching in unrelated donor bone marrow transplantation for patients with acquired severe aplastic anemia
1Department of Pediatrics, Nihon University School of Medicine, Tokyo, Japan; 2Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan; 3Department of Cell Transplantation and Regenerative Medicine, Tokai University School of Medicine, Isehara, Japan; 4Children’s Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan; 5Kanagawa Children’s Hospital...
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ژورنال
عنوان ژورنال: Haematologica
سال: 2009
ISSN: 0390-6078,1592-8721
DOI: 10.3324/haematol.2009.007583